Fort Qu'Appelle is a town in the Canadian province of Saskatchewan located in the Qu'Appelle River valley 70 km (43 mi) north-east of Regina, between Echo and Mission Lakes of the Fishing Lakes. It is not to be confused with the once-significant nearby town of Qu'Appelle. It was originally established in 1864 as a Hudson's Bay Company trading post. Fort Qu'Appelle, with its 1,919 residents in 2006, is at the junction of Highway 35, Highway 10, Highway 22, Highway 56, and Highway 215. The 1897 Hudson's Bay Company store, 1911 Grand Trunk Pacific Railway station, Fort Qu'Appelle Sanatorium, and the Treaty 4 Governance Centre in the shape of a teepee are all landmarks of this community. Additionally, the Noel Pinay sculpture of a man praying commemorates a burial ground, is a life-sized statue in a park beside Segwun Avenue.

The Qu'Appelle River is a river in the Canadian provinces of Saskatchewan and Manitoba that flows 430 kilometres (270 mi) east from Lake Diefenbaker in south-western Saskatchewan to join the Assiniboine River in Manitoba, just south of Lake of the Prairies, near the village of St. Lazare. It is in a region called the Prairie Pothole Region of North America, which extends throughout three Canadian provinces and five U.S. states. It is also within Palliser's Triangle and the Great Plains ecoregion.