The Qu'Appelle River is a river in the Canadian provinces of Saskatchewan and Manitoba that flows 430 kilometres (270 mi) east from Lake Diefenbaker in south-western Saskatchewan to join the Assiniboine River in Manitoba, just south of Lake of the Prairies, near the village of St. Lazare. It is in a region called the Prairie Pothole Region of North America, which extends throughout three Canadian provinces and five U.S. states. It is also within Palliser's Triangle and the Great Plains ecoregion.

Saskatchewan is a province in Western Canada, bordered on the west by Alberta, on the north by the Northwest Territories, on the east by Manitoba, to the northeast by Nunavut, and to the south by the United States. Saskatchewan and Alberta are the only landlocked provinces of Canada. In 2023, Saskatchewan's population was estimated at 1,225,493. Nearly 10% of Saskatchewan's total area of 651,900 km2 (251,700 sq mi) is fresh water, mostly rivers, reservoirs, and lakes.