Fort Resolution is a hamlet in the South Slave Region of the Northwest Territories, Canada. The community is situated at the mouth of the Slave River, on the shores of Great Slave Lake, and at the end of the Fort Resolution Highway. It is the headquarters of the Deninu Kųę́ First Nation, whose Chief is Louis Balsillie.

The South Slave Region is one of five administrative regions in the Northwest Territories of Canada. According to Municipal and Community Affairs the region consists of seven communities with the regional office situated in Fort Smith and a sub-office in Hay River. With the exception of Enterprise and Hay River the communities are predominantly First Nations.