François d'Andelot de Coligny was one of the leaders of French Protestantism during the French Wars of Religion. The son of Gaspard I de Coligny, he was the younger brother of Odet, cardinal de Châtillon and Gaspard de Coligny the admiral.

The French Wars of Religion were a series of civil wars between French Catholics and Protestants from 1562 to 1598. Between two and four million people died from violence, famine or disease directly caused by the conflict, and it severely damaged the power of the French monarchy. One of its most notorious episodes was the St. Bartholomew's Day massacre in 1572. The fighting ended with a compromise in 1598, when Henry of Navarre, who had converted to Catholicism in 1593, was proclaimed King Henry IV of France and issued the Edict of Nantes, which granted substantial rights and freedoms to the Huguenots. However, Catholics continued to disapprove of Protestants and of Henry, and his assassination in 1610 triggered a fresh round of Huguenot rebellions in the 1620s.