The Frances Perkins Building is the Washington, D.C. headquarters of the United States Department of Labor. It is located at 200 Constitution Avenue NW and sits above Interstate 395. The structure is named after Frances Perkins, the U.S. Secretary of Labor from 1933–1945 and the first female cabinet secretary in U.S. history.

The United States Department of Labor (DOL) is one of the executive departments of the U.S. federal government. It is responsible for the administration of federal laws governing occupational safety and health, wage and hour standards, unemployment benefits, reemployment services, and occasionally, economic statistics. It is headed by the secretary of labor, who reports directly to the president of the United States and is a member of the president's Cabinet.