Francis, Duke of Saxe-Coburg-Saalfeld, was a reigning Duke of Saxe-Coburg-Saalfeld, one of the ruling Thuringian dukes of the House of Wettin. As progenitor of a line of Coburg princes who, in the 19th and 20th centuries, ascended the thrones of several European realms, he is a patrilineal ancestor of the royal houses of Belgium and Bulgaria, as well as of several queens consort and empress consort of Mexico in the 1860s.

Saxe-Coburg-Saalfeld was one of the Saxon Duchies held by the Ernestine line of the Wettin Dynasty. Established in 1699, the Saxe-Coburg-Saalfield line lasted until the reshuffle of the Ernestine territories that occurred following the extinction of the Saxe-Gotha line in 1825, in which the Saxe-Coburg-Saalfeld line received Gotha, but lost Saalfeld to Saxe-Meiningen.