Francis II was King of the Two Sicilies. He was the last King of the Two Sicilies as successive invasions by Giuseppe Garibaldi and Victor Emmanuel II of Sardinia ultimately brought an end to his rule, as part of Italian unification. After he was deposed, the Kingdom of the Two Sicilies and the Kingdom of Sardinia were merged into the newly formed Kingdom of Italy.

The Kingdom of the Two Sicilies was a kingdom in Southern Italy from 1816 to 1861 under the control of a cadet branch of the Spanish Bourbons. The kingdom was the largest sovereign state by population and size in Italy before Italian unification, comprising Sicily and most of the area of today's Mezzogiorno in covering all of the Italian Peninsula south of the Papal States.