The Frankfurt Süd–Aschaffenburg railway was opened in 1848 and 1854 and was one of the oldest railways in Germany. It is now a double track electrified main line, beginning in Frankfurt South station (Südbahnhof) and running from Frankfurt's Frankfurt East station (Ostbahnhof) on the right bank of the Main via Hanau Hauptbahnhof to Aschaffenburg Hauptbahnhof.

Frankfurt (Main) Süd or Frankfurt Südbahnhof is one of three railway stations for long-distance train services in Frankfurt, Germany. Unlike Frankfurt Hauptbahnhof it is not a terminus but a through station, and has nine tracks with five platforms. It is a stopping station for some long-distance routes and for regional traffic. It is also one of the major rapid-transit railway hubs in the city with S-Bahn and U-Bahn services.