Frankfurt (Main) West station is a railway station for regional and S-Bahn services in Frankfurt, Germany, on the Main-Weser Railway, in the district of Bockenheim, near the Frankfurt Trade Fair grounds and the Bockenheim campus of the Goethe University Frankfurt.

The Rhine-Main S-Bahn system is an integrated rapid transit and commuter train system for the Frankfurt/Rhine-Main region, which includes the cities Frankfurt am Main, Wiesbaden, Mainz, Offenbach am Main, Hanau and Darmstadt. The network comprises nine S-Bahn lines, eight of which currently travel through the cornerstone of the system, a tunnel through central Frankfurt. The first section of this tunnel was opened on May 28, 1978. Further tunnel sections were opened in 1983 and 1990, before its completion in 1992. The system belongs to the Rhein-Main-Verkehrsverbund (RMV) and is operated by DB Regio, a subsidiary of Deutsche Bahn.