Frederick Kaplan
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Frederick S. Kaplan is an American medical doctor specializing in research of musculoskeletal disorders such as fibrodysplasia ossificans progressiva.
Frederick S. Kaplan
Endochondral ossification
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Endochondral ossification is one of the two essential pathways by which bone tissue is produced during fetal development and bone repair of the mammalian skeletal system, the other pathway being intra
Frederick Kaplan
…which did not occur in FOP. Also, the pattern of ossification was different in these patients, spreading in an intramembranous fashion rather than endochondral. In 2006, the magazine Newsweek named Kaplan as one of their "15 People Who Make America Great". In 2009, he was elected to the National Academy of…
A schematic representation of endochondral ossification.
A schematic for long bone endochondral ossification.
Light micrograph of undecalcified epiphyseal plate showing endochondral ossification: healthy chondrocytes (top) become degenerating ones (bottom), characteristically displaying a calcified extracellular matrix.
Zones of endochondral ossification.