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Frederick Sanger

Frederick Sanger was a British biochemist who twice won the Nobel Prize in Chemistry, one of only two people to have done so in the same category, the fourth person overall with two Nobel Prizes, the third person overall with two Nobel Prizes in the sciences. In 1958, he was awarded a Nobel Prize in Chemistry "for his work on the structure of proteins that of insulin". In 1980, Walter Gilbert and Sanger shared half of the chemistry prize "for their contributions concerning the determination of base sequences in nucleic acids"; the other half was awarded to Paul Berg "for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant DNA". Frederick Sanger was born on 13 August 1918 in Rendcomb, a small village in Gloucestershire, the second son of Frederick Sanger, a general practitioner, his wife, Cicely Sanger, he was one of three children. His brother, was only a year older, while his sister May was five years younger, his father had worked as an Anglican medical missionary in China but returned to England because of ill health.

He was 40 in 1916 when he married Cicely, four years younger. Sanger's father converted to Quakerism soon after his two sons were born and brought up the children as Quakers. Sanger's mother was the daughter of a wealthy cotton manufacturer and had a Quaker background, but was not a Quaker; when Sanger was around five years old the family moved to the small village of Tanworth-in-Arden in Warwickshire. The family was reasonably wealthy and employed a governess to teach the children. In 1927, at the age of nine, he was sent to the Downs School, a residential preparatory school run by Quakers near Malvern, his brother Theo was a year ahead of him at the same school. In 1932, at the age of 14, he was sent to the established Bryanston School in Dorset; this had a more liberal regime which Sanger much preferred. At the school he liked his teachers and enjoyed scientific subjects. Able to complete his School Certificate a year early, for which he was awarded seven credits, Sanger was able to spend most of his last year of school experimenting in the laboratory alongside his chemistry master, Geoffrey Ordish, who had studied at Cambridge University and been a researcher in the Cavendish Laboratory.

Working with Ordish made a refreshing change from sitting and studying books and awakened Sanger's desire to pursue a scientific career. In 1936 Sanger went to St John's College, his father had attended the same college. For Part I of his Tripos he took courses in physics, chemistry and mathematics but struggled with physics and mathematics. Many of the other students had studied more mathematics at school. In his second year he replaced physics with physiology, he took three years to obtain his Part I. For his Part II he obtained a 1st Class Honours. Biochemistry was a new department founded by Gowland Hopkins with enthusiastic lecturers who included Malcolm Dixon, Joseph Needham and Ernest Baldwin. Both his parents died from cancer during his first two years at Cambridge, his father was 60 and his mother was 58. As an undergraduate Sanger's beliefs were influenced by his Quaker upbringing, he was a member of the Peace Pledge Union. It was through his involvement with the Cambridge Scientists' Anti-War Group that he met his future wife, Joan Howe, studying economics at Newnham College.

They courted while he was studying for his Part II exams and married after he had graduated in December 1940. Under the Military Training Act 1939 he was provisionally registered as a conscientious objector, again under the National Service Act 1939, before being granted unconditional exemption from military service by a tribunal. In the meantime he undertook training in social relief work at the Quaker centre, Spicelands and served as a hospital orderly. Sanger began studying for a PhD in October 1940 under N. W. "Bill" Pirie. His project was to investigate. After little more than a month Pirie left Albert Neuberger became his adviser. Sanger changed his research project to study the metabolism of lysine and a more practical problem concerning the nitrogen of potatoes, his thesis had the title, "The metabolism of the amino acid lysine in the animal body". He was examined by Charles Harington and Albert Charles Chibnall and awarded his doctorate in 1943. Neuberger moved to the National Institute for Medical Research in London, but Sanger stayed in Cambridge and in 1943 joined the group of Charles Chibnall, a protein chemist who had taken up the chair in the Department of Biochemistry.

Chibnall had done some work on the amino acid composition of bovine insulin and suggested that Sanger look at the amino groups in the protein. Insulin could be purchased from the pharmacy chain Boots and was one of the few proteins that were available in a pure form. Up to this time Sanger had been funding himself. In Chibnall's group he was supported by the Medical Research Council and from 1944 until 1951 by a Beit Memorial Fellowship for Medical Research. Sanger's first triumph was to determine the complete amino acid sequence of the two polypeptide chains of bovine insulin, A and B, in 1952 and 1951, respectively. Prior to this it was assumed that proteins were somewhat amorphous. In determining these sequences, Sanger proved. To get to this point, Sanger refined a partition chromatography method first developed by Richard Laurence Millington Synge and Archer J

Chanson Illusionist

"Chanson Illusionist" is a song recorded by French animator and musician Sylvain Chomet for the official soundtrack to the 2010 animated film, The Illusionist. It was distributed digitally on 14 December 2010 through Warner Bros. Records and Milan Records, along with the rest of the parent album. Chomet wrote the piece while Terry Davies arranged its production. "Chanson Illusionist" was written by Chomet while its orchestral production was handled by Terry Davies, who conducted it. Acting as the composter, Chomet selected Isobel Griffiths and Lucy Whalley to handle the conduction of the accompanying orchestra while Sonia Slany led it, accompanied by a piano arrangement created by Gwilyn Simcock. In the recording, voice impersonations of Juliette Gréco, Les Frères Jacques, Georges Brassens, Yves Montand, Édith Piaf, Jacques Brel, Serge Gainsbourg are performed by an ensemble cast of voice actors. French impersonators Didier Gustin, Jil Aigrot, Frédéric Lebon fulfilled the task over Chomet's original composition, with several of them each impersonating several of the aforementioned singers.

Lasting four minutes and five seconds, Michael Phillips of the Chicago Tribune, described the composition as a "gentle waltz". William Ruhlmann, of AllMusic and CD Universe, thanked Chomet for the French and Scottish musical influence apparent in the production. Ruhlmann found it to be apparent and claimed that "the French aspect comes up right away". "Chanson Illusionist" was included on the official list of 41 contenders for the Academy Award for Best Original Song in 2010, but it did not received a nomination

Burong isda

Burong isda is a Filipino dish consisting of cooked rice and raw filleted fish fermented with salt and angkak for around a week. The dish is common in central Luzon, most notably in the province of Pampanga. Angkak may be omitted in western central Luzon, resulting in a white-colored version. Burong isda variants are named after the fish they were made with. Shrimp versions of the dish are known as burong balao-balao. Burong isda is similar to other fermented fish and rice dishes of Asia, including narezushi of Japanese cuisine and pla ra of Thai cuisine. All of these dishes rely on lactic acid fermentation to preserve the food. Binagoongan Daing Kinilaw Tapai Burong mangga Atchara

Running Down the Road

Running Down the Road is the second studio album by American folk singer Arlo Guthrie. Guthrie's version of the traditional folk tune "Stealin'" was featured in the film Two-Lane Blacktop; the cover shows the artist upon a Triumph TR6 Trophy motorcycle, pictured in the album's'gate'. All tracks composed by Arlo Guthrie. "Coming into Los Angeles" is the first song on Side Two of the original album. Side One "Oklahoma Hills" - 3:26 "Every Hand in the Land" – 2:18 "Creole Belle" - 3:43 "Wheel of Fortune" - 2:28 "Oh, in the Morning" - 4:51Side Two "Coming into Los Angeles" - 3:04 "Stealin'" - 2:46 "My Front Pages" - 3:47 "Living in the Country" - 3:16 "Running Down the Road" - 4:29 Arlo Guthrie - vocals, piano Clarence White - guitar Ry Cooder - guitar, bass Gene Parsons - drums, harmonica James Burton - guitar Chris Ethridge - bass Milt Holland - percussion Jerry Scheff - bass John Pilla - guitar Jim Gordon - drumsTechnicalBarry Feldman - executive producer Doug Botnick - engineer Henry Diltz - cover photography

2014 Atlantic Hockey Tournament

The 2014 Atlantic Hockey Tournament is the 10th Atlantic Hockey Tournament. It was played between March 7 and March 22, 2014, at campus locations and at the Blue Cross Arena in Rochester, New York; the winner of the tournament was the Robert Morris Colonials, who earned Atlantic Hockey's automatic bid to the 2014 NCAA Division I Men's Ice Hockey Tournament. The tournament features four rounds of play. In the first round the fifth and twelfth and eleventh, seventh and tenth, eighth and ninth seeds, as determined by the conference regular-season standings, played a best-of-three series with the winners advancing to the quarterfinals; the top four teams from the conference regular-season standings received a bye to the quarterfinals. There, the first seed and lowest-ranked first-round winner, the second seed and second-lowest-ranked first-round winner, the third seed and second-highest-ranked first-round winner, the fourth seed and the highest-ranked first-round winner played a best-of-three series, with the winners advancing to the semifinals.

In the semifinals, the highest and lowest seeds and second-highest and second-lowest seeds played a single game each, with the winners advancing to the championship game. The tournament champion received an automatic bid to the 2014 NCAA Division I Men's Ice Hockey Tournament. Note: GP = Games Played. D Doug Jessey. D Chris Rumble. F Ralph Cuddemi. F Greg Gibson. F Cody Wydo*.* Most Valuable Player

Strawbridge and Clothier Store, Jenkintown

The Strawbridge and Clothier Store is a historic department store building located at Jenkintown, Montgomery County, Pennsylvania. It was built by Strawbridge & Clothier in 1930-1931 and renovated and expanded in 1954, it closed in 1988. It is now multi-tenant; the original section is a four-story, steel frame structure faced in limestone and on a granite base in the Art Deco style. It has a flat slag roof with parapet; the building features piers that extend above the roof parapet, two-story projecting entrance pavilions, a one-story flat roofed extension with elegant display windows, two five-story towers. The addition is a three-story structure with a parking garage, it was built as the second suburban branch of Clothier. This Strawbridge & Clothier store closed in 1988. In the late 1990s, the building served as the headquarters of fast-growing online music retailer CDNow, it houses an Outback Steakhouse. The building was added to the National Register of Historic Places in 1988. Notes Media related to Strawbridge & Clothier Store, Jenkintown at Wikimedia Commons Strawbridge & Clothier company records at Hagley Museum and Library