University of Tübingen
The University of Tübingen the Eberhard Karls University of Tübingen, is a public research university located in the city of Tübingen, Baden-Württemberg, Germany. It is a German Excellence University, Tübingen is ranked as one of the best universities in Germany and is known as a centre for the study of medicine and theology and religion; the university's noted alumni include numerous presidents, ministers, EU Commissioners and judges of the Federal Constitutional Court. The university is associated with eleven Nobel laureates in the fields of medicine and chemistry; the University of Tübingen was founded in 1477 by Count Eberhard V the first Duke of Württemberg, a civic and ecclesiastic reformer who established the school after becoming absorbed in the Renaissance revival of learning during his travels to Italy. Its first rector was Johannes Nauclerus, its present name was conferred on it in 1769 by Duke Karl Eugen who appended his first name to that of the founder. The university became the principal university of the kingdom of Württemberg.
Today, it is one of nine state universities funded by the German federal state of Baden-Württemberg. The University of Tübingen has a history of innovative thought in theology, in which the university and the Tübinger Stift are famous to this day. Philipp Melanchthon, the prime mover in building the German school system and a chief figure in the Protestant Reformation, helped establish its direction. Among Tübingen's eminent students have been the astronomer Johannes Kepler. "The Tübingen Three" refers to Hölderlin and Schelling, who were roommates at the Tübinger Stift. Theologian Helmut Thielicke revived postwar Tübingen when he took over a professorship at the reopened theological faculty in 1947, being made administrative head of the university and President of the Chancellor's Conference in 1951; the university rose to the height of its prominence in the middle of the 19th century with the teachings of poet and civic leader Ludwig Uhland and the Protestant theologian Ferdinand Christian Baur, whose circle and students became known as the "Tübingen School", which pioneered the historical-critical analysis of biblical and early Christian texts, an approach referred to as "higher criticism."
The University of Tübingen was the first German university to establish a faculty of natural sciences, in 1863. DNA was discovered in 1868 at the University of Tübingen by Friedrich Miescher. Christiane Nüsslein-Volhard, the first female Nobel Prize winner in medicine in Germany works at Tübingen; the faculty for economics and business was founded in 1817 as the "Staatswissenschaftliche Fakultät" and was the first of its kind in Germany. The University played a leading role in efforts to legitimize the policies of the Third Reich as "scientific". Before the victory of the Nazi Party in the general election in March 1933, there were hardly any Jewish faculty and a few Jewish students. Physicist Hans Bethe was dismissed on 20 April 1933 because of "non-Aryan" origin. Religion professor Traugott Konstantin Oesterreich and the mathematician Erich Kamke were forced to take early retirement in both cases the "non-Aryan" origin of their wives. At least 1158 people were sterilized at the University Hospital.
In 1966, Joseph Ratzinger, who would become Pope Benedict XVI, was appointed to a chair in dogmatic theology in the Faculty of Catholic Theology at Tübingen, where he was a colleague of Hans Küng. In 1967, Jürgen Moltmann, one of the most influential Protestant theologians of the 20th century, was appointed Professor of Systematic Theology in the Faculty of Protestant Theology. Drafted in 1944 by Nazi Germany, he was an Allied prisoner of war 1945-1948, he was influenced by friend Ernst Bloch, the Marxist philosopher. In 1970, the university was restructured into a series of faculties as independent departments of study and research after the manner of French universities; the university made the headlines in November 2009 when a group of left-leaning students occupied one of the main lecture halls, the Kupferbau, for several days. The students' goal was to protest tuition fees and maintain that education should be free for everyone. In May 2010, Tübingen joined the Matariki Network of Universities together with Dartmouth College, Durham University, Queen’s University, University of Otago, University of Western Australia and Uppsala University.
The University of Tübingen undertakes a broad range of research projects in various fields. Among the more prominent ones in the natural sciences are the Hertie Institute for Clinical Brain Research, which focuses on general and cellular neurology as well as neurodegeneration, the Centre for Interdisciplinary Clinical Research, which deals with cell biology in diagnostics and therapy of organ system diseases. In the liberal arts, the University of Tübingen is noteworthy for having the only faculty of rhetoric in Germany – the department was founded by Walter Jens, an important intellectual and literary critic; the university boasts continued pre-eminence in its centuries-old traditions of research in the fields of philosophy and philology. Since at least the nineteenth century, Tübingen has been the home of world-class research in prehistoric studies and the study of antiquity, including the study of the ancient Near East.
Basel is a city in northwestern Switzerland on the river Rhine. Basel is Switzerland's third-most-populous city with about 180,000 inhabitants. Located where the Swiss and German borders meet, Basel has suburbs in France and Germany; as of 2016, the Swiss Basel agglomeration was the third-largest in Switzerland, with a population of 541,000 in 74 municipalities in Switzerland. The initiative Trinational Eurodistrict Basel of 62 suburban communes including municipalities in neighboring countries, counted 829,000 inhabitants in 2007; the official language of Basel is German, but the main spoken language is the local Basel German dialect. The city is known for its many internationally renowned museums, ranging from the Kunstmuseum, the first collection of art accessible to the public in Europe and the largest museum of art in the whole of Switzerland, to the Fondation Beyeler; the University of Basel, Switzerland's oldest university, the city's centuries-long commitment to humanism, have made Basel a safe haven at times of political unrest in other parts of Europe for such notable people as Erasmus of Rotterdam, the Holbein family, Friedrich Nietzsche and in the 20th century Hermann Hesse and Karl Jaspers.
The city of Basel is Switzerland's second-largest economic centre after the city of Zürich and has the highest GDP per capita in the country, ahead of the cantons of Zug and Geneva. In terms of value, over 94% of Basel City's goods exports are in the chemical and pharmaceutical sectors. With production facilities located in the neighboring Schweizerhalle, Basel accounts for 20% of Swiss exports and generates one third of the national product. Basel has been the seat of a Prince-Bishopric since the 11th century, joined the Swiss Confederacy in 1501; the city has been a commercial hub and an important cultural centre since the Renaissance, has emerged as a centre for the chemical and pharmaceutical industries in the 20th century. In 1897, Basel was chosen by Theodor Herzl as the location for the first World Zionist Congress, altogether the congress has been held there ten times over a time span of 50 years, more than in any other location; the city is home to the world headquarters of the Bank for International Settlements.
In 2019 Basel, was ranked among the ten most liveable cities in the world by Mercer together with Zürich and Geneva. There are traces of a settlement at the Rhine knee from the early La Tène period. In the 2nd century BC, there was a village of the Raurici at the site of Basel-Gasfabrik, to the northwest of the Old City identical with the town of Arialbinnum mentioned on the Tabula Peutingeriana; the unfortified settlement was abandoned in the 1st century BC in favour of an oppidum on the site of Basel Minster in reaction to the Roman invasion of Gaul. In Roman Gaul, Augusta Raurica was established some 20 km from Basel as the regional administrative centre, while a castra was built on the site of the Celtic oppidum; the city of Basel grew around the castra. In AD 83, Basel was incorporated into the Roman province of Germania Superior. Roman control over the area deteriorated in the 3rd century, Basel became an outpost of the Provincia Maxima Sequanorum formed by Diocletian; the Germanic confederation of the Alemanni attempted to cross the Rhine several times in the 4th century, but were repelled.
However, in the great invasion of AD 406, the Alemanni appear to have crossed the Rhine river a final time and settling what is today Alsace and a large part of the Swiss Plateau. From that time, Basel has been an Alemannic settlement; the Duchy of Alemannia fell under Frankish rule in the 6th century, by the 7th century, the former bishopric of Augusta Raurica was re-established as the Bishopric of Basel. Based on the evidence of a third solidus with the inscription Basilia fit, Basel seems to have minted its own coins in the 7th century. Under bishop Haito, the first cathedral was built on the site of the Roman castle replaced by a Romanesque structure consecrated in 1019. At the partition of the Carolingian Empire, Basel was first given to West Francia, but it passed to East Francia with the treaty of Meerssen of 870; the city was plundered and destroyed by a Magyar invasion in 917. The rebuilt city became part of Upper Burgundy, as such was incorporated into the Holy Roman Empire in 1032.
From the donation by Rudolph III of Burgundy of the Moutier-Grandval Abbey and all its possessions to Bishop Adalbero II of Metz in 999 until the Reformation, Basel was ruled by prince-bishops. In 1019, the construction of the cathedral of Basel began under Holy Roman Emperor. In 1225–1226, a bridge, now known as the Middle Bridge, was constructed by Bishop Heinrich von Thun and Lesser Basel founded as a bridgehead to protect the bridge; the bridge was funded by Basel's Jewish community who had settled there a century earlier. For many centuries to come Basel possessed the only permanent bridge over the river "between Lake Constance and the sea"; the Bishop allowed the furriers to establish a guild in 1226. About 15 guilds were established in the 13th century, they increased the town's, hence the bishop's, reputation and income from the taxes and duties on goods in Basel's expanding market. The plague came to Europe in 1347, but did not reach Basel until June 1349. The
White blood cell
White blood cells are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including lymphatic system. All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells and platelets. Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by cell lineage; these broadest categories can be further divided into the five main types: neutrophils, basophils and monocytes. These types are distinguished by their physical and functional characteristics. Monocytes and neutrophils are phagocytic. Further subtypes can be classified; the number of leukocytes in the blood is an indicator of disease, thus the white blood cell count is an important subset of the complete blood count.
The normal white cell count is between 4 × 109/L and 1.1 × 1010/L. In the US, this is expressed as 4,000 to 11,000 white blood cells per microliter of blood. White blood cells make up 1% of the total blood volume in a healthy adult, making them less numerous than the red blood cells at 40% to 45%. However, this 1 % of the blood makes a large difference to health. An increase in the number of leukocytes over the upper limits is called leukocytosis, it is normal. It is abnormal, when it is neoplastic or autoimmune in origin. A decrease below the lower limit is called leukopenia; this indicates a weakened immune system. The name "white blood cell" derives from the physical appearance of a blood sample after centrifugation. White cells are found in the buffy coat, a thin white layer of nucleated cells between the sedimented red blood cells and the blood plasma; the scientific term leukocyte directly reflects its description. It is derived from the Greek roots leuk- meaning "white" and cyt- meaning "cell".
The buffy coat may sometimes be green if there are large amounts of neutrophils in the sample, due to the heme-containing enzyme myeloperoxidase that they produce. All white blood cells are nucleated, which distinguishes them from the anucleated red blood cells and platelets. Types of leukocytes can be classified in standard ways. Two pairs of broadest categories classify them either by cell lineage; these broadest categories can be further divided into the five main types: neutrophils, basophils and monocytes. These types are distinguished by their physical and functional characteristics. Monocytes and neutrophils are phagocytic. Further subtypes can be classified. Granulocytes are distinguished from agranulocytes by their nucleus shape and by their cytoplasm granules; the other dichotomy is by lineage: Myeloid cells are distinguished from lymphoid cells by hematopoietic lineage. Lymphocytes can be further classified as T cells, B cells, natural killer cells. Neutrophils are the most abundant white blood cell, constituting 60-70% of the circulating leukocytes, including two functionally unequal subpopulations: neutrophil-killers and neutrophil-cagers.
They defend against fungal infection. They are first responders to microbial infection, they are referred to as polymorphonuclear leukocytes, although, in the technical sense, PMN refers to all granulocytes. They have a multi-lobed nucleus; this gives the neutrophils the appearance of having multiple nuclei, hence the name polymorphonuclear leukocyte. The cytoplasm may look transparent because of fine granules. Neutrophils are active in phagocytosing bacteria and are present in large amount in the pus of wounds; these cells are not able to die after having phagocytosed a few pathogens. Neutrophils are the most common cell type seen in the early stages of acute inflammation; the life span of a circulating human neutrophil is about 5.4 days. Eosinophils compose about 2-4% of the WBC total; this count fluctuates throughout the day and during menstruation. It rises in response to allergies, parasitic infections, collagen diseases, disease of the spleen and central nervous system, they are rare in the blood, but numerous in the mucous membranes of the respiratory and lower urinary tracts.
They deal with parasitic infections. Eosinophils are the predominant inflammatory cells in allergic reactions; the most important causes of eosinophilia include allergies such as asthma, hay fever, hives. They secrete chemicals that destroy these large parasites, such as hook worms and tapeworms, that are too big for any one WBC to phagocytize. In general, their nucleus is bi-lobed; the lobes are connected by a thin strand. The cytoplasm is full of granules that assume a characteristic pink-orange color with eosin stain
Deoxyribonucleic acid is a molecule composed of two chains that coil around each other to form a double helix carrying the genetic instructions used in the growth, development and reproduction of all known organisms and many viruses. DNA and ribonucleic acid are nucleic acids; the two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. Each nucleotide is composed of one of four nitrogen-containing nucleobases, a sugar called deoxyribose, a phosphate group; the nucleotides are joined to one another in a chain by covalent bonds between the sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone. The nitrogenous bases of the two separate polynucleotide strands are bound together, according to base pairing rules, with hydrogen bonds to make double-stranded DNA; the complementary nitrogenous bases are divided into two groups and purines. In DNA, the pyrimidines are cytosine. Both strands of double-stranded DNA store the same biological information.
This information is replicated as and when the two strands separate. A large part of DNA is non-coding, meaning that these sections do not serve as patterns for protein sequences; the two strands of DNA are thus antiparallel. Attached to each sugar is one of four types of nucleobases, it is the sequence of these four nucleobases along the backbone. RNA strands are created using DNA strands as a template in a process called transcription. Under the genetic code, these RNA strands specify the sequence of amino acids within proteins in a process called translation. Within eukaryotic cells, DNA is organized into long structures called chromosomes. Before typical cell division, these chromosomes are duplicated in the process of DNA replication, providing a complete set of chromosomes for each daughter cell. Eukaryotic organisms store most of their DNA inside the cell nucleus as nuclear DNA, some in the mitochondria as mitochondrial DNA, or in chloroplasts as chloroplast DNA. In contrast, prokaryotes store their DNA only in circular chromosomes.
Within eukaryotic chromosomes, chromatin proteins, such as histones and organize DNA. These compacting structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed. DNA was first isolated by Friedrich Miescher in 1869, its molecular structure was first identified by Francis Crick and James Watson at the Cavendish Laboratory within the University of Cambridge in 1953, whose model-building efforts were guided by X-ray diffraction data acquired by Raymond Gosling, a post-graduate student of Rosalind Franklin. DNA is used by researchers as a molecular tool to explore physical laws and theories, such as the ergodic theorem and the theory of elasticity; the unique material properties of DNA have made it an attractive molecule for material scientists and engineers interested in micro- and nano-fabrication. Among notable advances in this field are DNA origami and DNA-based hybrid materials. DNA is a long polymer made from repeating units called nucleotides.
The structure of DNA is dynamic along its length, being capable of coiling into tight loops and other shapes. In all species it is composed of two helical chains, bound to each other by hydrogen bonds. Both chains are coiled around the same axis, have the same pitch of 34 angstroms; the pair of chains has a radius of 10 angstroms. According to another study, when measured in a different solution, the DNA chain measured 22 to 26 angstroms wide, one nucleotide unit measured 3.3 Å long. Although each individual nucleotide is small, a DNA polymer can be large and contain hundreds of millions, such as in chromosome 1. Chromosome 1 is the largest human chromosome with 220 million base pairs, would be 85 mm long if straightened. DNA does not exist as a single strand, but instead as a pair of strands that are held together; these two long strands coil in the shape of a double helix. The nucleotide contains both a segment of the backbone of a nucleobase. A nucleobase linked to a sugar is called a nucleoside, a base linked to a sugar and to one or more phosphate groups is called a nucleotide.
A biopolymer comprising multiple linked nucleotides is called a polynucleotide. The backbone of the DNA strand is made from alternating sugar residues; the sugar in DNA is 2-deoxyribose, a pentose sugar. The sugars are joined together by phosphate groups that form phosphodiester bonds between the third and fifth carbon atoms of adjacent sugar rings; these are known as the 3′-end, 5′-end carbons, the prime symbol being used to distinguish these carbon atoms from those of the base to which the deoxyribose forms a glycosidic bond. When imagining DNA, each phosphoryl is considered to "belong" to the nucleotide whose 5′ carbon forms a bond therewith. Any DNA strand therefore has one end at which there is a phosphoryl attached to the 5′ carbon of a ribose and another end a
Ludwig Karl Martin Leonhard Albrecht Kossel was a German biochemist and pioneer in the study of genetics. He was awarded the Nobel Prize for Physiology or Medicine in 1910 for his work in determining the chemical composition of nucleic acids, the genetic substance of biological cells. Kossel isolated and described the five organic compounds that are present in nucleic acid: adenine, guanine and uracil; these compounds were shown to be nucleobases, are key in the formation of DNA and RNA, the genetic material found in all living cells. Kossel was an important influence on and collaborator with other important researchers in biochemistry, including Henry Drysdale Dakin, Friedrich Miescher, Edwin B. Hart, his professor and mentor, Felix Hoppe-Seyler. Kossel was editor of the Zeitschrift für Physiologische Chemie from 1895 until his death. Kossel conducted important research into the composition of protein, his research predicted the discovery of the polypeptide nature of the protein molecule; the Albrecht Kossel Institute for Neuroregeneration at the University of Rostock is named in his honor.
Kossel was born in Rostock, Germany as the son of the merchant and Prussian consul Albrecht Karl Ludwig Enoch Kossel and his wife Clara Jeppe Kossel. As a youth, Kossel attended the Gymnasium at Rostock, where he evidenced substantial interest in chemistry and botany. In 1872, Kossel attended the University of Strassburg to study medicine, he studied under Felix Hoppe-Seyler, head of the department of biochemistry, the only such institution in Germany at the time. He attended lectures by Anton de Bary, August Kundt, Baeyer, he completed his studies at University of Rostock, passed his German medical license exam in 1877. After completing his university studies, Kossel returned to the University of Strassburg as research assistant to Felix Hoppe-Seyler. At the time, Hoppe-Seyler was intensely interested in research concerning an acidic substance that had first been chemically isolated from pus cells by one of his former students, Friedrich Miescher, in 1869. Unlike protein, the substance contained considerable amounts of phosphorus, but with its high acidity, it was unlike any cellular substance that had yet been observed.
Kossel showed that the substance, called "nuclein", consisted of a protein component and a non-protein component. Kossel further described the non-protein component; this substance has become known as nucleic acid, which contains the genetic information found in all living cells. In 1883, Kossel left Strassburg to become Director of the Chemistry Division of the Physiological Institute at the University of Berlin. In this post, he worked under the supervision of Emil du Bois-Reymond. Kossel continued his previous work on the nucleic acids. During the period 1885 to 1901, he was able to isolate and name its five constituent organic compounds: adenine, guanine and uracil; these compounds are now known collectively as nucleobases, they provide the molecular structure necessary in the formation of stable DNA and RNA molecules. In 1895, Kossel was professor of physiology as well as director of the Physiological Institute at the University of Marburg. Around this time, he began investigations into the chemical composition of proteins, the alterations in proteins during transformation into peptone, the peptide components of cells, other investigations.
In 1896, Kossel discovered histidine worked out the classical method for the quantitative separation of the "hexone bases". He was the first to isolate theophylline, a therapeutic drug found in tea and cocoa beans. In 1901, Kossel was named to a similar post at Heidelberg University, became director of the Heidelberg Institute for Protein Investigation, his research predicted the discovery of the polypeptide nature of the protein molecule. The processes of life are like a drama, I am studying the actors, not the plot. There are many actors, it is their characters which make this drama. I seek to understand their peculiarities. Kossel was awarded the Nobel Prize in Physiology or Medicine in 1910 for his research in cell biology, the chemical composition of the cell nucleus, for his work in isolating and describing nucleic acids; the award was presented on 10 December 1910. In the autumn of 1911, Kossel was invited to the United States to deliver the Herter Lecture at Johns Hopkins. Traveling with his wife Luise and daughter Gertrude, he took the opportunity to travel and to visit acquaintances, one of, Eugene W. Hilgard, professor emeritus of agricultural chemistry at the University of California at Berkeley, his wife's cousin.
He visited and delivered lectures at several other universities, including the University of Chicago. On the occasion of his visit to New York City, Kossel was interviewed by a reporter from The New York Times. Kossel's English was very good, his self-effacing modesty is voluminously mentioned in the reporter's account, his Herter lecture at Johns Hopkins was titled, "The Proteins". This was the only time Kossel visited the United States. With his distinguished English pupil Henry Drysdale Dakin, Kossel investigated arginase, the ferment which hydrolyses arginine into urea and ornithine, he discovered agmatine in herring roe and devised a method for preparing it. Another of Kossel's students was American biochemist Edwin B. Hart, who would return to the United States to participate in the "Single-grain experiment" and be part of research teams that would determine the nutritive causes of anemia and goiter. Another was Otto Folin, an American che
International Standard Serial Number
An International Standard Serial Number is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is helpful in distinguishing between serials with the same title. ISSN are used in ordering, interlibrary loans, other practices in connection with serial literature; the ISSN system was first drafted as an International Organization for Standardization international standard in 1971 and published as ISO 3297 in 1975. ISO subcommittee TC 46/SC 9 is responsible for maintaining the standard; when a serial with the same content is published in more than one media type, a different ISSN is assigned to each media type. For example, many serials are published both in electronic media; the ISSN system refers to these types as electronic ISSN, respectively. Conversely, as defined in ISO 3297:2007, every serial in the ISSN system is assigned a linking ISSN the same as the ISSN assigned to the serial in its first published medium, which links together all ISSNs assigned to the serial in every medium.
The format of the ISSN is an eight digit code, divided by a hyphen into two four-digit numbers. As an integer number, it can be represented by the first seven digits; the last code digit, which may be 0-9 or an X, is a check digit. Formally, the general form of the ISSN code can be expressed as follows: NNNN-NNNC where N is in the set, a digit character, C is in; the ISSN of the journal Hearing Research, for example, is 0378-5955, where the final 5 is the check digit, C=5. To calculate the check digit, the following algorithm may be used: Calculate the sum of the first seven digits of the ISSN multiplied by its position in the number, counting from the right—that is, 8, 7, 6, 5, 4, 3, 2, respectively: 0 ⋅ 8 + 3 ⋅ 7 + 7 ⋅ 6 + 8 ⋅ 5 + 5 ⋅ 4 + 9 ⋅ 3 + 5 ⋅ 2 = 0 + 21 + 42 + 40 + 20 + 27 + 10 = 160 The modulus 11 of this sum is calculated. For calculations, an upper case X in the check digit position indicates a check digit of 10. To confirm the check digit, calculate the sum of all eight digits of the ISSN multiplied by its position in the number, counting from the right.
The modulus 11 of the sum must be 0. There is an online ISSN checker. ISSN codes are assigned by a network of ISSN National Centres located at national libraries and coordinated by the ISSN International Centre based in Paris; the International Centre is an intergovernmental organization created in 1974 through an agreement between UNESCO and the French government. The International Centre maintains a database of all ISSNs assigned worldwide, the ISDS Register otherwise known as the ISSN Register. At the end of 2016, the ISSN Register contained records for 1,943,572 items. ISSN and ISBN codes are similar in concept. An ISBN might be assigned for particular issues of a serial, in addition to the ISSN code for the serial as a whole. An ISSN, unlike the ISBN code, is an anonymous identifier associated with a serial title, containing no information as to the publisher or its location. For this reason a new ISSN is assigned to a serial each time it undergoes a major title change. Since the ISSN applies to an entire serial a new identifier, the Serial Item and Contribution Identifier, was built on top of it to allow references to specific volumes, articles, or other identifiable components.
Separate ISSNs are needed for serials in different media. Thus, the print and electronic media versions of a serial need separate ISSNs. A CD-ROM version and a web version of a serial require different ISSNs since two different media are involved. However, the same ISSN can be used for different file formats of the same online serial; this "media-oriented identification" of serials made sense in the 1970s. In the 1990s and onward, with personal computers, better screens, the Web, it makes sense to consider only content, independent of media; this "content-oriented identification" of serials was a repressed demand during a decade, but no ISSN update or initiative occurred. A natural extension for ISSN, the unique-identification of the articles in the serials, was the main demand application. An alternative serials' contents model arrived with the indecs Content Model and its application, the digital object identifier, as ISSN-independent initiative, consolidated in the 2000s. Only in 2007, ISSN-L was defined in the
A scientist is someone who conducts scientific research to advance knowledge in an area of interest. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature called natural philosophy, a precursor of natural science, it was not until the 19th century that the term scientist came into regular use after it was coined by the theologian and historian of science William Whewell in 1833. The term'scientist' was first coined by him for Mary Somerville because the term "man of science", more custom at that time, was inappropriate here. In modern times, many scientists have advanced degrees in an area of science and pursue careers in various sectors of the economy such as academia, industry and nonprofit environments; the roles of "scientists", their predecessors before the emergence of modern scientific disciplines, have evolved over time. Scientists of different eras have had different places in society, the social norms, ethical values, epistemic virtues associated with scientists—and expected of them—have changed over time as well.
Accordingly, many different historical figures can be identified as early scientists, depending on which characteristics of modern science are taken to be essential. Some historians point to the Scientific Revolution that began in 16th century as the period when science in a recognizably modern form developed, it wasn't until the 19th century that sufficient socioeconomic changes occurred for scientists to emerge as a major profession. Knowledge about nature in classical antiquity was pursued by many kinds of scholars. Greek contributions to science—including works of geometry and mathematical astronomy, early accounts of biological processes and catalogs of plants and animals, theories of knowledge and learning—were produced by philosophers and physicians, as well as practitioners of various trades; these roles, their associations with scientific knowledge, spread with the Roman Empire and, with the spread of Christianity, became linked to religious institutions in most of European countries.
Astrology and astronomy became an important area of knowledge, the role of astronomer/astrologer developed with the support of political and religious patronage. By the time of the medieval university system, knowledge was divided into the trivium—philosophy, including natural philosophy—and the quadrivium—mathematics, including astronomy. Hence, the medieval analogs of scientists were either philosophers or mathematicians. Knowledge of plants and animals was broadly the province of physicians. Science in medieval Islam generated some new modes of developing natural knowledge, although still within the bounds of existing social roles such as philosopher and mathematician. Many proto-scientists from the Islamic Golden Age are considered polymaths, in part because of the lack of anything corresponding to modern scientific disciplines. Many of these early polymaths were religious priests and theologians: for example, Alhazen and al-Biruni were mutakallimiin. During the Italian Renaissance scientists like Leonardo Da Vinci, Galileo Galilei and Gerolamo Cardano have been considered as the most recognizable polymaths.
During the Renaissance, Italians made substantial contributions in science. Leonardo Da Vinci made significant discoveries in anatomy; the Father of modern Science,Galileo Galilei, made key improvements on the thermometer and telescope which allowed him to observe and describe the solar system. Descartes was not only a pioneer of analytic geometry but formulated a theory of mechanics and advanced ideas about the origins of animal movement and perception. Vision interested the physicists Young and Helmholtz, who studied optics and music. Newton extended Descartes' mathematics by inventing calculus, he investigated light and optics. Fourier founded a new branch of mathematics — infinite, periodic series — studied heat flow and infrared radiation, discovered the greenhouse effect. Girolamo Cardano, Blaise Pascal Pierre de Fermat, Von Neumann, Khinchin and Wiener, all mathematicians, made major contributions to science and probability theory, including the ideas behind computers, some of the foundations of statistical mechanics and quantum mechanics.
Many mathematically inclined scientists, including Galileo, were musicians. There are many compelling stories in medicine and biology, such as the development of ideas about the circulation of blood from Galen to Harvey. During the age of Enlightenment, Luigi Galvani, the pioneer of the bioelectromagnetics, discovered the animal electricity, he discovered that a charge applied to the spinal cord of a frog could generate muscular spasms throughout its body. Charges could make frog legs jump if the legs were no longer attached to a frog. While cutting a frog leg, Galvani's steel scalpel touched a brass hook, holding the leg in place; the leg twitched. Further experiments confirmed this effect, Galvani was convinced that he was seeing the effects of what he called animal electricity, the life force within the muscles of the frog. At the University of Pavia, Galvani's colleague Alessandro Volta was able to reproduce the results, but was sceptical o