From Hell is a 2001 period detective horror film directed by the Hughes Brothers and written by Terry Hayes and Rafael Yglesias. It is loosely based on the graphic novel of the same name by Alan Moore and Eddie Campbell about the Jack the Ripper murders. The film stars Johnny Depp as Frederick Abberline, the lead investigator of the murders, and Heather Graham as Mary Kelly, a prostitute targeted by the Ripper. Other cast members include Ian Holm, Robbie Coltrane, Ian Richardson and Jason Flemyng.

Albert Hughes and Allen Hughes, known together professionally as the Hughes brothers, are American film directors and producers. The pair, who are twins, are known for co-directing visceral, and often violent, movies, including 1993's Menace II Society, 1995's Dead Presidents, 2001's From Hell and 2010's The Book of Eli. The brothers did most of their collaboration between 1993 and 2001. Since 2004, when Albert moved to Prague, Czech Republic, he and Allen have only directed one film together, The Book of Eli in 2010. They have been involved in directing and producing film and television projects separately since 2005.