Functional Ensemble of Temperament is a neurochemical model suggesting specific functional roles of main neurotransmitter systems in the regulation of behaviour.
The structure of neurochemical framework Functional Ensemble of Temperament (FET) corresponds to 12 universal aspects of construction of behaviour. Shadowed text relates to temperament traits; blue capital letters highlight the lead, and grey – supporting neurotransmitters for the given trait. Note: 5-HT: serotonin; DA: dopamine; NE: noradrenalin; ACh: acetylcholine; Glu: Glutamate; H: histamine; A: adenosine; Estr: estrogen; NP: neuropeptides; GH:
Basal ganglia
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The basal ganglia or basal nuclei are a group of subcortical nuclei found in the brains of vertebrates. Positioned at the base of the forebrain and the top of the midbrain, they have strong connection
Functional Ensemble of Temperament
…Physical Tempo speed of integration of an action in physical manipulations with objects with well-defined scripts of actions DA-GABA interaction in basal ganglia, DOR, with involvement of ACh interneurons, NP and adenosine Social-verbal Tempo the preferred speed of speech and ability to understand fast speech…
Schematic of basal ganglia overlain on the cerebral cortex
Basal ganglia
The left side of Fig.1 shows a region of the prefrontal cortex receiving multiple inputs from other regions, as cortico-cortical activity. The input from B is the strongest of these. The right side of Fig. 1 shows the input signals also being fed to the basal ganglia circuitry. The output from here, back to the same region, is shown to modify the strength of the input from B, by adding strength to the input from C thereby modifying the strongest signal from B to C. (Thalamic involvement is implicit but not shown).