Galesburg Santa Fe Station was a railway station in the west central Illinois town of Galesburg. The station was along the Atchison, Topeka and Santa Fe Railway's main line and served trains such as the Super Chief and El Captain. After Amtrak took over intercity rail in the United States, it was served by trains such as the Lone Star (1971–1979) and the Southwest Chief (1971–1996).

Galesburg is a city in Knox County, Illinois, United States. The city is 45 miles (72 km) northwest of Peoria. At the 2010 census, its population was 32,195. It is the county seat of Knox County and the principal city of the Galesburg Micropolitan Statistical Area, which includes all of Knox and Warren counties.