Gemünden am Main is a town in the Main-Spessart district in the Regierungsbezirk of Lower Franconia (Unterfranken) in Bavaria, Germany and lies roughly 40 km down the Main from Würzburg. Gemünden has around 10,000 inhabitants.

The Main is the longest tributary of the Rhine. It rises as the White Main in the Fichtel Mountains of northeastern Bavaria and flows west through central Germany for 525 kilometres (326 mi) to meet the Rhine below Rüsselsheim, Hesse. The cities of Mainz and Wiesbaden are close to the confluence.