The General Building, also called the Tennessee General Building or the First Bank Building, is an office high rise located in downtown Knoxville, Tennessee. Constructed in 1925, the 14-story building is the only high rise designed by Charles I. Barber, and has over the years housed the offices of dozens of banks, physicians, and various financial and architectural firms. The Lexington, Tennessee-based First Bank is the current anchor tenant. In 1988, the General Building was listed on the National Register of Historic Places for its architecture and its role in Knoxville's commercial history.

Charles Ives Barber was an American architect, active primarily in Knoxville, Tennessee, and vicinity, during the first half of the 20th century. He was cofounder of the firm, Barber & McMurry, through which he designed or codesigned buildings such as the Church Street Methodist Episcopal Church, South, the General Building, and the Knoxville YMCA, as well as several campus buildings for the University of Tennessee and numerous elaborate houses in West Knoxville. Several buildings designed by Barber have been listed on the National Register of Historic Places.