The South Market Historic District is a cluster of five buildings at the intersection of Market Street and Church Avenue in Knoxville, Tennessee, United States, listed on the National Register of Historic Places in 1996. The buildings, which include the Cherokee Building, the Ely Building, the Cunningham, the Stuart, and the Cate, were built circa 1895—1907, and were used for both office space and residential space. Several prominent Knoxville physicians and three marble companies operated out of the buildings in this district in the early 1900s.

The General Building, also called the Tennessee General Building or the First Bank Building, is an office high rise located in downtown Knoxville, Tennessee. Constructed in 1925, the 14-story building is the only high rise designed by Charles I. Barber, and has over the years housed the offices of dozens of banks, physicians, and various financial and architectural firms. The Lexington, Tennessee-based First Bank is the current anchor tenant. In 1988, the General Building was listed on the National Register of Historic Places for its architecture and its role in Knoxville's commercial history.