Genesee Brewing Company is an American brewery located along the Genesee River in Rochester, New York. From 2000 to 2009, the company was known as the High Falls Brewing Company. In 2009, High Falls was acquired by the capital investment firm KPS Capital. Together with newly acquired Labatt USA, KPS merged the two companies as North American Breweries. Along with this change, High Falls Brewery changed its name back to the original "Genesee Brewing Company" operating under the North American Breweries name. In October 2012, North American Breweries was purchased by FIFCO.

Rochester is a city in the U.S. state of New York and the county seat of Monroe County. It is the fourth-most populous city and 10th most-populated municipality in New York, with a population of 211,328 at the 2020 census. The city forms the core of the larger Rochester metropolitan area in Western New York, with a population of over 1.09 million residents. Throughout its history, Rochester has acquired several nicknames based on local industries; it has been known as "the Flour City" and "the Flower City" for its dual role in flour production and floriculture, and as the "Imaging Capital of the World" for its association with film and still photography.