Genome editing
Videos
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early geneti
Groups of engineered nucleases. Matching colors signify DNA recognition patterns
Plants, animals and human genes that are successfully targeted using ZFN, which demonstrates the generality of this approach
Overview of GEEN workflow and editing possibilities
Gene targeting
Videos
Gene targeting is a biotechnological tool used to change the DNA sequence of an organism. It is based on the natural DNA-repair mechanism of homology directed repair, including homologous recombinatio
A chimeric mouse gene targeted for the agouti coat color gene, with its offspring
Wild-type Physcomitrella and knockout mosses: Deviating phenotypes induced in gene-disruption library transformants. Physcomitrella wild-type and transformed plants were grown on minimal Knop medium to induce differentiation and development of gametophores. For each plant, an overview (upper row, scale bar corresponds to 1 mm) and a close-up (bottom row, scale bar equals 0.5 mm) is shown. A, Haploid wild-type moss plant completely covered with leafy gametophores and close-up of wild-type leaf. B–E, Different mutants.