Brigadier General George Miller Sternberg was a U.S. Army physician who is considered the first American bacteriologist, having written Manual of Bacteriology (1892). After he survived typhoid and yellow fever, Sternberg documented the cause of malaria (1881), discovered the cause of lobar pneumonia (1881), and confirmed the roles of the bacilli of tuberculosis and typhoid fever (1886).

Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic member of the genus Streptococcus. They are usually found in pairs (diplococci) and do not form spores and are non motile. As a significant human pathogenic bacterium S. pneumoniae was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity studies.