Germantown Pike is a historic road in Pennsylvania that opened in 1687, running from Philadelphia northwest to Collegeville. The road is particularly notable for the "imposing mansions" that existed in the Germantown neighborhood in Philadelphia. The road was left in ruins after the British destroyed it in the Revolutionary War during the 1777 Battle of Germantown, and was not rebuilt until 1809. Portions of Germantown Pike were signed as U.S. Route 422 (US 422) before the latter was rerouted along a freeway alignment to King of Prussia.

U.S. Route 422 (US 422) is a 271-mile-long (436 km) spur route of US 22 split into two segments in the U.S. states of Ohio and Pennsylvania. The western segment of US 422 runs from downtown Cleveland, Ohio, east to Ebensburg, Pennsylvania. The eastern segment, located entirely within Pennsylvania, runs from Hershey east to King of Prussia, near Philadelphia. US 422 Business serves as a business route into each of four towns along the way.