The Grand Junction Railway (GJR) was an early railway company in the United Kingdom, which existed between 1833 and 1846. The line built by the company, which opened in 1837, linked the Liverpool and Manchester Railway to Birmingham via Warrington, Crewe, Stafford and Wolverhampton. This was the first trunk railway to be completed in England, and arguably the world's first long-distance railway with steam traction. It terminated at Curzon Street Station in Birmingham, which it shared with the London and Birmingham Railway (L&BR), whose adjacent platforms gave an interchange with full connectivity between Liverpool, Manchester and London.

The West Coast Main Line (WCML) is one of the most important railway corridors in the United Kingdom, connecting the major cities of London and Glasgow with branches to Birmingham, Manchester, Liverpool and Edinburgh. It is one of the busiest mixed-traffic railway routes in Europe, carrying a mixture of intercity rail, regional rail, commuter rail and rail freight traffic. The core route of the WCML runs from London to Glasgow for 399 miles (642 km) and was opened from 1837 to 1881. With additional lines deviating to Northampton, Birmingham, Manchester, Liverpool and Edinburgh, this totals a route mileage of 700 miles (1,127 km). The Glasgow–Edinburgh via Carstairs line connects the WCML to Edinburgh. However, the main London–Edinburgh route is the East Coast Main Line. Several sections of the WCML form part of the suburban railway systems in London, Coventry, Birmingham, Manchester, Liverpool and Glasgow, with many more smaller commuter stations, as well as providing links to more rural towns.