The Grand Valley is an extended populated valley, approximately 30 miles (48 km) long and 5 miles (8.0 km) wide, located along the Colorado River in Mesa County in western Colorado and Grand County in eastern Utah in the Western United States. The valley contains the city of Grand Junction, as well as other smaller communities such as Fruita and Palisade. The valley is a major fruit-growing region that contains many orchards and vineyards, and is home to one of two designated American Viticultural Areas in Colorado: the Grand Valley AVA. It takes its name from the "Grand River", the historical name of the Colorado River upstream from its confluence with the Green River that was used by locals in the late 19th and early 20th century. The valley is the most densely populated area on the Colorado Western Slope, with Grand Junction serving as an unofficial capital of the region, as a counterpoint to Denver on the eastern slope of the Rocky Mountains in the Colorado Front Range. Interstate 70 and U.S. Highway 6 run through the valley from west-to-east. The Grand Valley is part of the larger Colorado Plateau desert lands.

The Colorado River is one of the principal rivers in the Southwestern United States and in northern Mexico. The 1,450-mile-long (2,330 km) river, the 5th longest in the United States, drains an expansive, arid watershed that encompasses parts of seven U.S. states and two Mexican states. The name Colorado derives from the Spanish language for "colored reddish" due to its heavy silt load. Starting in the central Rocky Mountains of Colorado, it flows generally southwest across the Colorado Plateau and through the Grand Canyon before reaching Lake Mead on the Arizona–Nevada border, where it turns south toward the international border. After entering Mexico, the Colorado approaches the mostly dry Colorado River Delta at the tip of the Gulf of California between Baja California and Sonora.