The Great Sandy Desert is an interim Australian bioregion, located in the northeast of Western Australia straddling the Pilbara and southern Kimberley regions and extending east into the Northern Territory. It is the second largest desert in Australia after the Great Victoria Desert and encompasses an area of 284,993 square kilometres (110,036 sq mi). The Gibson Desert lies to the south and the Tanami Desert lies to the east of the Great Sandy Desert.

The Pilbara is a large, dry, thinly populated region in the north of Western Australia. It is known for its Aboriginal peoples; its ancient landscapes; the red earth; and its vast mineral deposits, in particular iron ore. It is also a global biodiversity hotspot for subterranean fauna.