The Great Siege of Malta occurred in 1565 when the Ottoman Empire attempted to conquer the island of Malta, then held by the Knights Hospitaller. The siege lasted nearly four months, from 18 May to 8 September 1565.

The Ottoman Empire, historically and colloquially known as the Turkish Empire, was an imperial realm that spanned much of Southeast Europe, West Asia, and North Africa from the 14th to early 20th centuries; it also controlled parts of southeastern Central Europe between the early 16th and early 18th centuries.