Greco is an Italian wine grape that may be of Greek origin. The name relates to both white and black grape varieties. While there is more land area dedicated to Greco nero, the Greco bianco is the grape most commonly referred to by "Greco". In the Campania region it is used to produce the denominazione di origine controllata e garantita (DOCG) wine Greco di Tufo. In Calabria, it is used to make the denominazione di origine controllata (DOC) wine Greco di Bianco. The name "Greco" is sometimes used as a synonym for several varieties of supposed Greek origins-most notably Trebbiano.

Italian wine is produced in every region of Italy. Italy is the world's largest wine producer, as well as the country with the widest variety of indigenous grapevine in the world, with an area of 702,000 hectares under vineyard cultivation, and contributing a 2013–2017 annual average of 48.3 million hl of wine. In 2018 Italy accounted for 19 per cent of global production, ahead of France and Spain. Italian wine is both exported around the world and popular domestically among Italians, who consume an average of 42 litres per capita, ranking fifth in world wine consumption.