Greene County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 45,736. The county seat is Paragould, which sits atop Crowley's Ridge.

Crowley's Ridge is a geological formation that rises 250 to 550 feet (170 m) above the alluvial plain of the Mississippi embayment in a 150-mile (240 km) line from southeastern Missouri to the Mississippi River near Helena, Arkansas. It is the most prominent feature in the Mississippi Alluvial Plain between Cape Girardeau, Missouri, and the Gulf of Mexico.