Guangzhounan railway station is located in Shibi, Panyu District, Guangzhou, Guangdong Province, China. It is a large modern rail terminal 17 kilometres (11 mi) south of central Guangzhou. For a brief time it was Asia's largest railway station by area when it officially started operation in early 2010.

Panyu, alternately romanized as Punyu, is one of 11 urban districts of the prefecture-level city of Guangzhou, the capital of Guangdong Province, China. It was a separate county-level city before its incorporation into modern Guangzhou in 2000. The present district covers an area of about 530 km2 (200 sq mi).