Guna Yala, formerly known as San Blas, is a comarca indígena in northeast Panama. Guna Yala is home to the indigenous people known as the Gunas. Its capital is Gaigirgordub. It is bounded on the north by the Caribbean Sea, on the south by the Darién Province and Emberá-Wounaan, on the east by Colombia, and on the west by the province of Colón.

The Guna are an indigenous people of Panama and Colombia. Guna people live in three politically autonomous comarcas or autonomous reservations in Panama, and in a few small villages in Colombia. There are also communities of Guna people in Panama City, Colón, and other cities. Most Guna live on small islands off the coast of the comarca of Guna Yala known as the San Blas Islands. The other two Guna comarcas in Panama are Kuna de Madugandí and Kuna de Wargandí. They are Guna-speaking people who once occupied the central region of what is now Panama and the neighboring San Blas Islands and still survive in marginal areas.