Guthrie County is a county located in the U.S. state of Iowa. As of the 2020 census, the population was 10,623. The county seat is Guthrie Center. The county was formed on January 15, 1851, and named after Captain Edwin B. Guthrie, who died in the Mexican–American War.

Iowa Highway 4 is a state highway which runs from north to south across the state of Iowa. It is 146 miles (235 km) long, beginning at an intersection with Iowa Highway 44 in Panora and ending at the Minnesota state line north of Estherville. It continues north as Minnesota State Highway 4. The route was created on January 1, 1969, when several route designations were changed to match other states' route numbers. Before 1969, Iowa 4 was known as Iowa 17.