The Hanford Site is a decommissioned nuclear production complex operated by the United States federal government on the Columbia River in Benton County in the U.S. state of Washington. It has also been known as Site W and the Hanford Nuclear Reservation. Established in 1943 as part of the Manhattan Project, the site was home to the Hanford Engineer Works and B Reactor, the first full-scale plutonium production reactor in the world. Plutonium manufactured at the site was used in the first atomic bomb, which was tested in the Trinity nuclear test, and in the Fat Man bomb used in the bombing of Nagasaki.

The Columbia River is the largest river in the Pacific Northwest region of North America. The river forms in the Rocky Mountains of British Columbia, Canada. It flows northwest and then south into the U.S. state of Washington, then turns west to form most of the border between Washington and the state of Oregon before emptying into the Pacific Ocean. The river is 1,243 miles long, and its largest tributary is the Snake River. Its drainage basin is roughly the size of France and extends into seven states of the United States and one Canadian province. The fourth-largest river in the United States by volume, the Columbia has the greatest flow of any river entering the Pacific outside of Asia, and the 36th greatest discharge of any river in the world.