Harrison Gray Otis, was a businessman, lawyer, and politician, becoming one of the most important leaders of the United States' first political party, the Federalists. He was a member of the Otis family.

The Federalist Party was a conservative and nationalist American political party and the first political party in the United States. It dominated the national government under Alexander Hamilton from 1789 to 1801. The party was defeated by the Democratic-Republican Party in 1800, and it became a minority party while keeping its stronghold in New England. It made a brief resurgence by opposing the War of 1812, then collapsed with its last presidential candidate in 1816. Remnants lasted for a few years afterwards.