The Havana Conference of 1946 was a historic meeting of United States Mafia and Cosa Nostra leaders in Havana, Cuba. Supposedly arranged by Charles "Lucky" Luciano, the conference was held to discuss important mob policies, rules, and business interests. The Havana Conference was attended by delegations representing crime families throughout the United States. The conference was held during the week of December 22, 1946, at the Hotel Nacional. The Havana Conference is considered to have been the most important mob summit since the Atlantic City Conference of 1929. Decisions made in Havana resonated throughout US crime families during the ensuing decades.

Charles "Lucky" Luciano was an Italian-born gangster who operated mainly in the United States. He started his criminal career in the Five Points Gang and was instrumental in the development of the National Crime Syndicate. Luciano is considered the father of modern organized crime in the United States for the establishment of the Commission in 1931, after he abolished the boss of bosses title held by Salvatore Maranzano following the Castellammarese War. He was also the first official boss of the modern Genovese crime family.