The "Greater Manchester Model" of NHS health care was a system uniquely devolved within England, by way of close integration with the Greater Manchester Combined Authority and local authorities, led by the Mayor of Greater Manchester. In July 2022 the Greater Manchester integrated care system took over responsibility for health and social care in the conurbation. The financial plan for 2022–23 had an initial shortage of £187 million.

Manchester Royal Infirmary (MRI) is a large NHS teaching hospital in Chorlton-on-Medlock, Manchester, England. Founded by Charles White in 1752 as part of the voluntary hospital movement of the 18th century, it is now a major regional and national medical centre. It is the largest hospital within Manchester University NHS Foundation Trust, and based on its Oxford Road Campus in South Manchester where it shares a site with the Royal Manchester Children's Hospital, Manchester Royal Eye Hospital and Saint Mary's Hospital as well as several other educational and research facilities. The Hospital is also a key site for medical educational within Manchester, serving as a main teaching hospital for School of Medical Sciences, University of Manchester.