Hedgesville is a town in Berkeley County, West Virginia, United States, in the state's Eastern Panhandle region. The population was 318 at the 2010 census. The town sits on WV 9, roughly 13 miles east of Berkeley Springs. In addition to its legal definition, Hedgesville has come to be the common name for the large and sparsely inhabited area of West Virginia's Eastern Panhandle bordered by the Potomac River to the North and East, a southern border defined roughly by an imaginary line from the city of Martinsburg to the tip of Virginia, and Berkeley Springs to the West.

West Virginia Route 9 (WV 9) is a major east–west state highway located in the eastern extents of West Virginia's Eastern Panhandle. The western terminus of the route is at the Maryland state line on the north edge of Paw Paw, where WV 9 becomes Maryland Route 51 (MD 51) upon crossing the Potomac River. The eastern terminus is at the Virginia state line at Keyes Gap near Mannings, West Virginia, where WV 9 continues onward as Virginia State Route 9 (SR 9).