Hemerythrin is an oligomeric protein responsible for oxygen transport in the marine invertebrate phyla of sipunculids, brachiopods, in a single annelid worm genus, Magelona. Myohemerythrin is a monomeric O2-binding protein found in the muscles of marine invertebrates. Hemerythrin and myohemerythrin are colorless when deoxygenated, but turn a violet-pink in the oxygenated state. Hemerythrin does; the names of the blood oxygen transporters hemoglobin, hemerythrin, do not refer to the heme group, instead these names are derived from the Greek word for blood. Recent evidence has revealed hemerythrin to be a multi-functional protein – contributing to innate immunity and anterior tissue regeneration in worms; the mechanism of dioxygen binding is unusual. Most O2 carriers operate via formation of dioxygen complexes, but hemerythrin holds the O2 as a hydroperoxide; the site that binds O2 consists of a pair of iron centres. The iron atoms are bound to the protein through the carboxylate side chains of a glutamate and aspartates as well as through five histidine residues.
Hemerythrin and myohemerythrin are described according to oxidation and ligation states of the iron center: The uptake of O2 by hemerythrin is accompanied by two-electron oxidation of the diferrous centre to produce a hydroperoxide complex. The binding of O2 is described in this diagram: Deoxyhemerythrin contains two high-spin ferrous ions bridged by hydroxyl group. One iron is hexacoordinate and another is pentacoordinate. A hydroxyl group serves as a bridging ligand but functions as a proton donor to the O2 substrate; this proton-transfer result in the formation of a single oxygen atom bridge in oxy- and methemerythrin. O2 binds to the pentacoordinate Fe2+ centre at the vacant coordination site. Electrons are transferred from the ferrous ions to generate the binuclear ferric centre with bound peroxide. Hemerythrin exists as a homooctamer or heterooctamer composed of α- and β-type subunits of 13–14 kDa each, although some species have dimeric and tetrameric hemerythrins; each subunit has a four-α-helix fold binding a binuclear iron centre.
Because of its size hemerythrin is found in cells or "corpuscles" in the blood rather than free floating. Unlike hemoglobin, most hemerythrins lack cooperative binding to oxygen, making it 1/4 as efficient as hemoglobin. In some brachiopods though, hemerythrin shows cooperative binding of O2. Cooperative binding is achieved by interactions between subunits: the oxygenation of one subunit increases the affinity of a second unit for oxygen. Hemerythrin affinity for carbon monoxide is lower than its affinity for O2, unlike hemoglobin which has a high affinity for CO. Hemerythrin's low affinity for CO poisoning reflects the role of hydrogen-bonding in the binding of O2, a pathway mode, incompatible with CO complexes which do not engage in hydrogen bonding; the hemerythrin/HHE cation-binding domain occurs as a duplicated domain in hemerythrins and related proteins. This domain binds iron in hemerythrin, but can bind other metals in related proteins, such as cadmium in the Nereis diversicolor hemerythrin.
It is found in the NorA protein from Cupriavidus necator, this protein is a regulator of response to nitric oxide, which suggests a different set-up for its metal ligands. A protein from Cryptococcus neoformans that contains haemerythrin/HHE cation-binding domains is involved in nitric oxide response. A Staphylococcus aureus protein containing this domain, iron-sulfur cluster repair protein ScdA, has been noted to be important when the organism switches to living in environments with low oxygen concentrations. Coates, C. J. Decker, H.. "Immunological properties of oxygen transport proteins: hemoglobin and hemerythrin". Cell. Mol. Life Sci. 74: 293–317. Doi:10.1007/s00018-016-2326-7. PMC 5219038. PMID 27518203. CS1 maint: multiple names: authors list Karlsen, O. A. Ramsevik, L. Bruseth, L. J. Larsen, Ø. Brenner, A. Berven, F. S. Jensen, H. B. and Lillehaug, J. R.. "Characterization of a prokaryotic haemerythrin from the methanotrophic bacterium Methylococcus capsulatus". FEBS J. 272: 2428–2440. Doi:10.1111/j.1742-4658.2005.04663.x.
PMID 15885093. CS1 maint: multiple names: authors list Stenkamp, R. E.. "Dioxygen and hemerythrin". Chem. Rev. 94: 715–726. Doi:10.1021/cr00027a008. 1HMD - PDB structure of deoxyhemerythrin Themiste dyscrita 1HMO – PDB structure of oxyhemerythrin from Themiste dyscrita 2MHR – PDB structure of azido-met myohemerythrin from Themiste zostericola IPR002063 – InterPro entry for hemerythrin
Headley Britannia, stable name Brit, was a mare who competed at the highest levels of the equestrian sport of eventing. Small for the sport, her jumping ability and willingness propelled her to the top of the sport. Headley Britannia was by one of the top eventing stallions in Britain, who first competed at the Advanced level with Andrew Nicholson as a seven-year-old; the stallion has been a top producer of eventers, dressage horses, Grade A show jumpers. Headley Britannia's greatest accomplishments include a win at the 2006 Burghley Horse Trials, the first mare in 33 years to do so, a win at the 2007 Badminton Horse Trials, the first mare in 53 years, a win at the 2009 Rolex Kentucky Three Day, she came third at the 2006 Luhmuhlen Three Day Event, a great accomplishment after having taken a fall the previous year on cross-country and contracting a virus which nearly killed her. She was an alternative to the 2006 World Equestrian Games, but when not called, was switched to the Burghley Horse Trials.
She is one of only two horses in history to have won all three of the top four-star events, has had a Breyer model made of her. In 2007 her owners Katinka and Neil Thorburn gave her to her rider, Lucinda Fredericks. After winning Badmintion she went to stud for embryo transfer. Both foals carried by surrogate mares; the first of Brit's two foals was born in a chestnut filly with a white star. Fredericks confirmed that the second foal had been born in May 2008 this one being a dark bay colt. Strangely the foals resemble much like their parents, the filly, Little Britannia, is chestnut with a white star like her dam, the colt, Britannia's Mail looking remarkably similar to his sire Jaguar Mail, dark bay in colour. Both foals are now part of Team Fredericks Foal syndicate which people can buy shares for Britannia's Mail is available for stallion services On March 15, 2012 it was announced by Team Fredericks that Headley Britannia would retire at Badminton Horse Trials. Due to the cancellation of Badminton in 2012 Badminton have agreed to hold this at the 2013 event instead.
Always small compared to the competition, her competitive spirit, sheer guts and a Will To Win have propelled her to the top. The plan is to enjoy competing her at a much lower level, breed more foals by Embryo Transfer and hand the reins over to 8 year old Ellie, champing at the bit to take the ride on. "It has been wonderful that Brit has been able to end her eventing career on a high at top level in a fit and healthy state," she added. Headley Britannia was euthanized at age 21 on 1 April 2014. Team Fredericks website
The Burchard-Bélaváry family is an aristocratic family of Hungarian origin who gave many personalities. Its comes from the Both de Bajna branch of the Both family, family Magnates of Hungary whose records date back to 1282, its name was Both de Szikava et Bélavár. Johann I Burchart von Bélaváry, who gave a famous dynasty of pharmacists in Tallinn, in Estonia, in the Raeapteek. György Both de Szikava et Bélavár, royal judge, captain of the Devín Castle. Dávid Bélaváry de Szikava and high official of the Kingdom of Hungary. Miklós Bélavary, son of Dávid, Grand Treasurer of Upper Hungary, military governor of Upper Hungary. Blood court. Dávid Belleváry II, grandson of David and son of Miklós. Officer in the Chamber of Kassa, collecting royal taxes and Imperial Commissioner, he became a kuruc hero in the Rákóczi's War of Independence. Johann Conrad Burchard von Bélaváry, Russian major, knight of the Order of St. George. Fromhold Johann Burchard-Bélaváry, Kapitan 2nd rank in the Imperial Russian Navy.
Konrád Bélaváry de Sikava, governor of Nubia. Konrád Burchard-Bélaváry, Consul general of Brazilia in Budapest, Business magnate, member of the House of Magnats. Rudolf/Rezsö von Burchard-Bélavary, son of Konrad. PhD in economics and political science, business magnate and Councillor and Chef de service to the Ministry of the Interior. Andor Burchard-Bélaváry. PhD in economics and political science, businessman, he has the title of Senior Councillor of the Government. Julius-Konrad Gyula Burchard-Bélaváry, captain of Hussar, major in the Hungarian army during the Hungarian Revolution in 1848, he was next to his friend general count Henryk Dembiński, he became the CEO of the French champagne Delbeck and president of the Union of Great Brands, in Reims. István Burchard-Bélaváry, artist. Marcel Burchard-Bélaváry, French commandant, writer, he is killed in the beginnings of the First World War. Nobility and royalty of the Kingdom of Hungary Hungarian heraldry Austria-Hungary Magyar Heraldikai és Geneológiai Társaság, Budapest, 1894, 1899, 1901, 1902, 1926 Récits de famille, Histoire de la Famille Burchard-Bélavàry, by Cdt Marcel Burchard-Bélavary, Berger-Levrault et Cie, Nancy, 1906.
Turul, 1901 Nagykanizsa – Romlottvár, by George Szekér dipl. Architecte, 2007, Budapest The Business Strategy of Fathers and Sons:A Hungarian Family in the 19th and 20th Centuries, Klement Judit, ed. in AETAS – Journal of history and related disciplines pdf
Walnut Park East is a neighborhood of St. Louis, Missouri. Walnut Park East is one of several neighborhoods in northwest St. Louis, its borders are West Florissant Avenue to the northeast, Emerson Avenue to the southeast, Interstate 70 to the southwest and west, Riverview Boulevard to the northwest. Northwest High School Northwest Junior High School Walnut Park Elementary School Aspire Academy In 2010 Walnut Park East's racial makeup was 96.7% Black, 1.5% Two or More Races, 1.3% White, 0.1% Native American, 0.3% Some Other Race. 0.8% of the people were of Hispanic or Latino origin
The first around the world sailing record for circumnavigation of the world was Juan Sebastián Elcano and the remaining members of Ferdinand Magellan's crew who completed their journey in 1522. The first solo record was set by Joshua Slocum in the Spray; the current record holders are IDEC 3, skippered by Francis Joyon in 40 days, 23 hours, 30 minutes and 30 seconds for a crewed journey, François Gabart with Macif in 42 days, 16 hours, 40 minutes and 35 seconds for a solo journey. Most races or solo attempts start from Europe. Due to the configuration of the continents, sailing around the world consists of sailing on the Southern Ocean around the Antarctica continent, passing south of Cape Horn, Cape of Good Hope and Cape Leeuwin. Since 1918 the Panama Canal is an option but the locks must be entered and exited using engine power. Large stretches of the canal can be crossed under sail power. Sailing around the world can be done by two directions: westward; the dominant winds and currents make the voyage eastwards on the Southern hemisphere faster, most skippers and yachts who race prefer this route.
Today, the multihulls hold the best times. Leisure yacht skippers who prefer tropical seas more go westward, using the trade winds; the Jules Verne Trophy is awarded to the skipper who breaks the outright record, starting from an imaginary line between the Créac'h lighthouse on Ouessant Island and the Lizard Lighthouse, UK. The records are homologated by the World Sailing Speed Record Council. According to the WSSRC, for around the world sailing records, there is a rule saying that the length must be at least 21,600 nmi calculated along the shortest possible track from the starting port and back that does not cross land and does not go below 63°S; the great-circle distance formulas are to be used, assuming that the great circle length is 21,600 nmi. It is allowed to have one single waypoint to lengthen the calculated track; the equator must be crossed. In reality, this means that the boat should pass a waypoint at or not far from the antipode of the starting port of the journey. For example, the Vendée Globe starts at 46°N 2°W, has a waypoint at 57°S 180°E, makes the distance requirement.
The participants don't have to go to the antipode at 46°S 178°E since the rounding of Africa gives extra distance. The most famous races around the world are: The Vendée Globe a non-stop solo race run using the IMOCA 60 Class; the Ocean Race, a stopping crewed race using the Volvo Ocean 65 and IMOCA 60 class. Known as the Whitbread Round The World Race and the Volvo Ocean Race; the VELUX 5 Oceans Race a stopping solo race run using the IMOCA 60 Class known as the BOC Challenge as Around Alone. The Barcelona World Race a non-stop two handed race run using the IMOCA 60 Class; the Clipper Round the World Yacht Race a stopping crewed race for amateur crews using the Clipper 70 Class. Former races including: The Sunday Times Golden Globe Race, held in 1968-1969, the first round-the-world yacht race; the BT Global Challenge, was a race followed the westward route. The Race, was a race held in 2000; the Oryx Quest, held starting from Qatar. This route is the more demanding one, as it faces the dominant currents.
There are records. As of February 2010, no record has been homologated. In May 2006, Dee Caffari became the first woman to sail around the world alone non-stop and single-handed westward on the Monohull Aviva, in 178 days; the rules for intermediate records are set by the WSSRC. Equator to Equator Indian Ocean Pacific Ocean South Atlantic Ocean From the Atlantic Ocean: Equator => Cape Agulhas => Around Antarctica => Cape Horn => Equator from Cape Agulhas, South Africa to Tasmania south point, Tasmania south point, to Cape Horn From Cape Horn to Cape Agulhas, South Africa From the cape Horn, cutting the longitude 67°16'W, up to the Equator Circumnavigation List of circumnavigations List of youth solo sailing circumnavigationsCompetitions and prizes Global Challenge Jules Verne Trophy The race Oryx Quest Vendée GlobeOther speed sailing records Speed sailing record World Sailing Speed Record Council Transatlantic sailing record
Dick Thompson Morgan was a U. S. Representative from Oklahoma. Born at Prairie Creek, Indiana, a few miles southwest of Terre Haute, Morgan attended the country schools and the Prairie Creek High School. In 1876 he received a bachelor's degree and in 1878 a master's degree both from Union Christian College, Indiana, he became a professor of mathematics in that college. He graduated from Central Law School, Indiana, in 1880. Morgan commenced practice in Terre Haute, Indiana. Morgan served as member of the Illinois House of Representatives in 1880 and 1881, he was appointed register of the United States land office at Woodward in Oklahoma Territory, by President Theodore Roosevelt in 1904 and served until May 1, 1908. Morgan was elected as a Republican to the five succeeding Congresses. Beginning on March 3, 1909, he represented the 2nd district. In 1915, after redistricting due to the 1910 Census, he represented the 8th congressional district until his unexpected death in 1920, he was once known as the "father of the Federal Trade Commission."
Morgan introduced the first bill to establish such a commission on January 12, 1912, made the first speech on the House floor urging its adoption on February 21, 1912 and reintroduced a amended version of the bill in 1913. He was a member of the Claims and Canals, Expenditures in the Treasury Department, Public Lands, Judiciary committees. Morgan became an expert on Rural Credits, sponsoring the 1916 rural credits law that created the federal land bank system. In 1878 he married Ora Heath, their son, Porter Heath Morgan, was born in 1880. On July 4, 1920, Morgan died of pneumonia in Danville, while returning from Washington, D. C. to Oklahoma. Dick Thompson Morgan is interred in Rose Hill Burial Park in Oklahoma. Morgan's Digest of Oklahoma Statutes and Supreme Court Decisions Morgan's Manual of the United States Homestead and Mining Laws Morgan's School Land Manual Land Credits: A Plea for the American Farmer Served as President and Treasurer of the Western Investment Co. the publisher of the periodical Oklahoma Real Estate Register.
List of United States Congress members who died in office United States Congress. "Dick Thompson Morgan". Biographical Directory of the United States Congress. Dick T. Morgan Collection at the Carl Albert Center Dick T. Morgan, late a representative from Oklahoma, Memorial addresses delivered in the House of Representatives and Senate frontispiece 1922