Henry Cabot Lodge Jr. was an American diplomat and politician who represented Massachusetts in the United States Senate and served as United States Ambassador to the United Nations in the administration of President Dwight D. Eisenhower. In 1960, he was the Republican nominee for Vice President on a ticket with Richard Nixon, who had served two terms as Eisenhower's vice president. The Republican ticket narrowly lost to Democrats John F. Kennedy and Lyndon B. Johnson; Lodge later served as a diplomat in the administrations of Kennedy, Johnson, Nixon, and Gerald Ford and was a presidential contender in 1964.

The 1960 United States presidential election was the 44th quadrennial presidential election. It was held on Tuesday, November 8, 1960. In a closely contested election, Democratic Senator John F. Kennedy defeated the incumbent Republican Vice President Richard Nixon. This was the first election in which 50 states participated, marking the first participation of Alaska and Hawaii, and the last in which the District of Columbia did not. This made it the only presidential election where the threshold for victory was 269 electoral votes. It was also the first election in which an incumbent president—in this case, Dwight D. Eisenhower—was ineligible to run for a third term because of the term limits established by the 22nd Amendment.