Henry Melchior Muhlenberg, was a German-born Lutheran clergyman and missionary. Born in Einbeck, Muhlenberg immigrated to the Province of Pennsylvania in response to demands from Lutherans for missionary work in the colony. Muhlenberg was integral to the founding of the first Lutheran church body or denomination in North America, and is considered the patriarch of the Lutheran Church in the United States.

The Pennsylvania Ministerium was the first Lutheran church body in North America. With the encouragement of Henry Melchior Muhlenberg (1711–1787), the Ministerium was founded at a Church Conference of Lutheran clergy on August 26, 1748. The group was known as the "German Evangelical Lutheran Ministerium of North America" until 1792, when it adopted the name "German Evangelical Lutheran Ministerium of Pennsylvania and Adjacent States".