Hesse-Homburg was a state of the Holy Roman Empire and a sovereign member of the German Confederation. It was formed into a separate landgraviate in 1622 by the landgrave of Hesse-Darmstadt; it was to be ruled by his son, although it did not become independent of Hesse-Darmstadt until 1668. It was briefly divided into Hesse-Homburg and Hesse-Homburg-Bingenheim; but these parts were reunited in 1681.

The Grand Duchy of Hesse and by Rhine was a grand duchy in western Germany that existed from 1806 to 1918. The grand duchy originally formed from the Landgraviate of Hesse-Darmstadt in 1806 as the Grand Duchy of Hesse. It assumed the name Hesse und bei Rhein in 1816 to distinguish itself from the Electorate of Hesse, which had formed from neighbouring Hesse-Kassel. Colloquially, the grand duchy continued to be known by its former name of Hesse-Darmstadt.