David Henry Hickman High School is a public secondary school in Columbia, Missouri, United States, serving students in grades 9–12. Built in 1927, it is the oldest of four high schools in the Columbia Public Schools, with admission based primarily on the locations of students' homes. Hickman is also one of the largest high schools in Missouri and has perennially strong academic, athletic, and arts programs.

Columbia is a city in the U.S. state of Missouri. It is the county seat of Boone County and home to the University of Missouri. Founded in 1821, it is the principal city of the three-county Columbia metropolitan area. It is Missouri's fourth most populous with an estimated 128,555 residents in 2022.