The High Hills of Santee, sometimes known as the High Hills of the Santee, is a long, narrow hilly region in the western part of Sumter County, South Carolina. It has been called "one of the state's most famous areas". The High Hills of Santee region lies north of the Santee River and east of the Wateree River, one of the two rivers that join to form the Santee. It extends north almost to the Kershaw county line and northeasterly to include the former summer resort town of Bradford Springs. Since 1902 the town has been included in Lee County.

Sumter County is a county located in the U.S. state of South Carolina. As of the 2020 census, the population was 105,556. Its county seat is Sumter.