The history of the Jews in Latin America began with conversos who joined the Spanish and Portuguese expeditions to the continents. The Alhambra Decree of 1492 led to the mass conversion of Spain's Jews to Catholicism and the expulsion of those who refused to do so. However, the vast majority of conversos never made it to the New World and remained in Spain slowly assimilating to the dominant Catholic culture. This was due to the requirement by Spain's Blood Statutes to provide written documentation of Old Christian lineage to travel to the New World. However, the first Jews came with the first expedition of Christopher Columbus, including Rodrigo de Triana and Luis De Torres.

The history of the Jews in Argentina goes back to the early sixteenth century, following the Jewish expulsion from Spain. Sephardi Jews fleeing persecution immigrated with explorers and colonists to settle in what is now Argentina, in spite of being forbidden from travelling to the American colonies. In addition, many of the Portuguese traders in the Viceroyalty of the Río de la Plata were Jewish. An organized Jewish community, however, did not develop until after Argentina gained independence from Spain in 1816. By mid-century, Jews from France and other parts of Western Europe, fleeing the social and economic disruptions of revolutions, began to settle in Argentina.