The history of the Southern United States spans back thousands of years to the first evidence of human occupation. The Paleo-Indians were the first peoples to inhabit the Americas and what would become the Southern United States. By the time Europeans arrived in the 15th century, the region was inhabited by the Mississippian people, well known for their mound-building cultures, building some of the largest cities of the Pre-Columbian United States. European history in the region would begin with the earliest days of the exploration. Spain, France, and especially England explored and claimed parts of the region.

Plantation complexes were common on agricultural plantations in the Southern United States from the 17th into the 20th century. The complex included everything from the main residence down to the pens for livestock. Until the abolition of slavery, such plantations were generally self-sufficient settlements that relied on the forced labor of enslaved people.