The Hokkaidō Development Commission , sometimes referred to as Hokkaidō Colonization Office or simply Kaitakushi, was a government agency in early Meiji Japan. Tasked with the administration, economic development, and securing of the northern frontier in what, at the time of establishment, was known as Ezo, it was established in 1869 and disbanded in 1882.

The Ainu are an ethnic group comprising related Indigenous peoples who are native to northern Japan, including Hokkaido and Northeast Honshu, as well as the land surrounding the Sea of Okhotsk, such as Sakhalin, the Kuril Islands, the Kamchatka Peninsula, and the Khabarovsk Krai; they have occupied these areas known to them as "Ainu Mosir", since before the arrival of the modern Japanese and Russians. These regions are often referred to as Ezochi (蝦夷地) and its inhabitants as Emishi (蝦夷) in historical Japanese texts.