Holy Sepulchre Cemetery is a Roman Catholic cemetery in Rochester, New York. Its original parcel was purchased in 1871 under Rochester’s first bishop, the Most Reverend Bernard J. McQuaid. The cemetery’s charter was granted by the State of New York in 1872 and a Board of Trustees was formed with Bishop McQuaid serving as its chairman.

Rochester is a city in the U.S. state of New York and the county seat of Monroe County. It is the fourth-most populous city and 10th most-populated municipality in New York, with a population of 211,328 at the 2020 census. The city forms the core of the larger Rochester metropolitan area in Western New York, with a population of over 1.09 million residents. Throughout its history, Rochester has acquired several nicknames based on local industries; it has been known as "the Flour City" and "the Flower City" for its dual role in flour production and floriculture, and as the "Imaging Capital of the World" for its association with film and still photography.