Hotel Meliá is a historic colonial style family owned and operated hotel located in the Ponce Historic Zone in Ponce, Puerto Rico. It is the oldest continuously operating hotel in Puerto Rico. Hotel Meliá, which was founded over 60 years before the much larger Meliá Hotels International chain opened its first lodging facility, bears no relation to the multi-hotel chain headquartered in Spain.

The Ponce Historic Zone is a historic district in downtown Ponce, Puerto Rico, consisting of buildings, plazas and structures with distinctive architectures such as Neoclásico Isabelino and the Ponce Creole, a local architectural style developed between the 19th- and early 20th-centuries. The zone goes by various names, including Traditional Ponce, Central Ponce, Historic Ponce, and Ponce Historic District.