The House of Mukhrani is a Georgian princely family that is a branch of the former royal dynasty of Bagrationi, from which it sprang early in the 16th century, receiving in appanage the domain of Mukhrani, in the Kingdom of Kartli. The family — currently the seniormost genealogical line of the entire Bagrationi dynasty — has since been known as Mukhranbatoni.

The Bagrationi dynasty is a royal dynasty which reigned in Georgia from the Middle Ages until the early 19th century, being among the oldest extant Christian ruling dynasties in the world. In modern usage, the name of the dynasty is sometimes Hellenized and referred to as the Georgian Bagratids, also known in English as the Bagrations.