Houston County is a county located in the southeastern corner of the U.S. state of Alabama. As of the 2020 census the population was 107,202. Its county seat is Dothan, which is located on the border and partially in adjacent Henry County.

Dothan ( DOH-thən) is a city in and the county seat of Houston County in the U.S. state of Alabama. A slight portion of the city extends into Dale and Henry counties. It had a population of 71,072 at the 2020 census, making it Alabama's eighth-largest city by population and the 5th largest in Alabama by total area. It is near the state's southeastern corner, about 20 miles (32 km) west of Georgia and 16 miles (26 km) north of Florida. It is named after the biblical city where Joseph's brothers threw him into a cistern and sold him into slavery in Egypt.