Human sacrifice was common in many parts of Mesoamerica, so the rite was nothing new to the Aztecs when they arrived at the Valley of Mexico, nor was it something unique to pre-Columbian Mexico. Other Mesoamerican cultures, such as the Purépechas and Toltecs, and the Maya performed sacrifices as well and from archaeological evidence, it probably existed since the time of the Olmecs, and perhaps even throughout the early farming cultures of the region. However, the extent of human sacrifice is unknown among several Mesoamerican civilizations. What distinguished Aztec practice from Maya human sacrifice was the way in which it was embedded in everyday life. These cultures also notably sacrificed elements of their own population to the gods.

The Aztecs were a Mesoamerican culture that flourished in central Mexico in the post-classic period from 1300 to 1521. The Aztec people included different ethnic groups of central Mexico, particularly those groups who spoke the Nahuatl language and who dominated large parts of Mesoamerica from the 14th to the 16th centuries. Aztec culture was organized into city-states (altepetl), some of which joined to form alliances, political confederations, or empires. The Aztec Empire was a confederation of three city-states established in 1427: Tenochtitlan, city-state of the Mexica or Tenochca, Texcoco, and Tlacopan, previously part of the Tepanec empire, whose dominant power was Azcapotzalco. Although the term Aztecs is often narrowly restricted to the Mexica of Tenochtitlan, it is also broadly used to refer to Nahua polities or peoples of central Mexico in the prehispanic era, as well as the Spanish colonial era (1521–1821). The definitions of Aztec and Aztecs have long been the topic of scholarly discussion ever since German scientist Alexander von Humboldt established its common usage in the early 19th century.